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Thursday 3 November 2016
Highlighted Article: LC-MS for Determination of Three Methoxyflavones from Kaempferia parviflora in rat Plasma and Application to Pharmacokinetic Study
LC-MS for Determination of Three Methoxyflavones from Kaempferia parviflora in rat Plasma and Application to Pharmacokinetic Study
Author(s):
Sarunya Tuntiyasawasdikul and Bungorn Sripanidkulchai Pages 371 - 378 (8)
Abstract:
Background: Methoxyflavones are isolated from Kaempferia parviflora, a Thai herb used in traditional medicine. The method of quantification of low level of methoxyflavones in biological samples needs to be optimized.
Objectives: To develop and validate a sensitive liquid chromatography-tandem mass spectrometry (LCMS) for the determination of methoxyflavones in rat plasma and apply for pharmacokinetic study.
Method: Chromatographic separation was achieved on a reverse phase C18 column, using acetonitrile and 0.5% formic acid in water in a ratio of 10:90 v/v to 50:50 v/v as the mobile phase, and a flow-rate of 0.2 ml/min at 25°C. LC–MS detection was performed under positive ionization with selective ion monitoring using target ions.
Results: The calibration curve showed good linearity in the concentration range of 10–3000 ng/ml. The limits of detection (LOD) and quantification (LOQ) were 0.43-0.78 ng/ml and 0.93-2.35 ng/ml, respectively. The intra-day and the inter-day variances were less than 6.41% and 12.96%. The mean recovery of methoxyflavones was 73.73- 99.76%. The assay was successfully applied to a pharmacokinetics study in rats that used a topical application of 15% K. parviflora extract in IPM-based vehicle. After topical administration, the plasma concentration of methoxyflavones continuously increased up to 48 h, indicating prolonged absorption of methoxyflavones into systemic circulation, with the maximum concentration (Cmax) of methoxyflavones being 401.94 ng/ml at 1 h.
Conclusion: The current method has been successfully applied to the determination of methoxyflavones in rat plasma and was used to study its pharmacokinetics under topical administration.
Keywords:
Kaempferia parviflora, methoxyflavones, LC-MS, pharmacokinetics, topical, validation.
Affiliation:
Center for Research and Development of Herbal Health Products, Khon Kaen University, Khon Kaen, 40002 Thailand.
Graphical Abstract:
For More Information Please Visit Our Website Current Pharmaceutical Analysis
Wednesday 26 October 2016
Most Accessed Article: A Novel Application of Three Phase Hollow Fiber Based Liquid Phase Microextraction (HF-LPME) for the HPLC Determination of Tamsulosin from Biological Fluids
A Novel Application of
Three Phase Hollow Fiber Based Liquid Phase Microextraction (HF-LPME) for the
HPLC Determination of Tamsulosin from Biological Fluids
Author(s):
Roghayeh A. Afshari and Mahnaz QomiPages
258-265 (8)
Abstract:
Background: Tamsulosin is used for the treatment of difficult urination, a common symptom of an enlarged prostate.
Objective: In the present paper, for the first
time a microextraction technique was introduced for the detection and
determination of tamsulosin in urine and plasma samples.
Method: Procedure for extraction of tamsulosin
consists of hollow ber based liquid phase microextraction (HF-LPME) followed by
high performance liquid chromatography (HPLC) coupled with ultraviolet (UV)
detection. The organic liquid membrane consists of 1-Octanol immobilized in the
pores of a hollow fiber. A pH gradient was applied to migrate analytes from the
sample solution with pH 10.5, through the organic liquid membrane into an
acidic acceptor solution with pH 3.0 which was located inside the lumen of
hollow fiber.
Results: Extraction recoveries greater than
80% were obtained in different biological matrices which resulted in
preconcentration factors greater than 102 and acceptable repeatability (2.5
< RSD% <3.5).
Conclusion: The method offers good linearity
with estimation of coefficacy higher than 0.9990. Finally, it was applied for
the determination and quantification of tamsulosin in human plasma and urine
samples.
Keywords:
Tamsulosin, high performance liquid
chromatography, hollow ber based liquid phase microextraction, Microextraction.
Affiliation:
Department of medicinal chemistry,
pharmaceutical sciences research center, University of Pharmaceutical sciences
branch Islamic Azad Tehran, Iran.
Graphical Abstract:
Thursday 20 October 2016
Wednesday 12 October 2016
An efficient HPLC method for determination of syringic acid liposome in rats plasma and mice tissues: Pharmacokinetic and biodistribution application
An efficient HPLC method for determination of syringic acid liposome in rats plasma and mice tissues: Pharmacokinetic and biodistribution application
Current Pharmaceutical Analysis, Volume 12 (E-pub ahead of print)
Author(s): Congyong Sun, Yangyang Yuan, Emmanuel Omari Siaw, Shanshan Tong, Yuan Zhu, Qilong Wang, Yuanwen Wang, Qiuyu Wei, Jiangnan Yu and Ximing Xu.
Affiliation: Department of Pharmaceutics, School of Pharmacy, Center for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University, Zhenjiang, People’s Republic of China.
Abstract
Objective: This study aims to establish an efficient, sensitive and specific analytical method (in vitro and in vivo) for syringic acid. Method: Syringic acid loaded liposome was prepared and characterized. In vitro and in vivo chromatographic conditions for the determination of syringic acid were investigated, with the application verified by pharmacokinetics and biodistribution studies. Results: The developed liposomal formulation produced homogeneous regular, spherical and multilamellar-shaped liposome. Efficient HPLC method for the analysis of syringic acid was established and validated. The chromatographic separation was performed on a Waters symmetry C18 column (4.6 × 150 mm, 5 μm) at 25 °C by using mobile phases of 30 % methanol and 70 % acetic acid solution (0.1 %) (in vitro) and 28 % methanol and 72 % acetic acid solution (0.1 %) (in vivo) at a flow rate of 0.8 mL/min. The wavelength was set at 272 nm. Vanillin was used as internal standard for the in vivo analysis. The established linearity ranges of SA were 1 - 100 μg/mL (R2 = 0.9997) in vitro and 0.125 – 64 μg/mL (R2 = 0.9991) in vivo. In vitro accuracy of the method was > 99%, and in vivo accuracies were between 91.23 % - 109.54 %, while the precisions met the acceptance criterion. In vivo HPLC method was also confirmed by pharmacokinetics and biodistribution studies. Conclusion: Established HPLC method exhibited high linearity, precision, accuracy and specificity, could be used for quantitative determination of SA in vitro and in vivo.Keywords:
Syringic acid; liposome; HPLC; quantitative analysis; biodistribution .
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Thursday 6 October 2016
New Issue :: Current Pharmaceutical Analysis , 12 Issue 4
Current Pharmaceutical Analysis publishes expert reviews and original research articles on all the most recent advances in pharmaceutical and biomedical analysis. All aspects of the field are represented including drug analysis, analytical methodology and instrumentation. The journal is essential to all involved in pharmaceutical, biochemical and clinical analysis.
Articles from the journal Current Pharmaceutical Analysis , Volume 12 Issue 4:
- An Overview of Different Analytical Techniques for Leukotriene Antagonists in Different Matrices
- Simultaneous Determination of Doxofylline and its Metabolite Theophylline in Rat Plasma by Ultra Performance Liquid Chromatography
- Effect of Electrospray Ionization Source Parameters on Pharmaceuticals Analysis Using Quadrupole Time-of-Flight Mass Spectrometry
- Development and Validation of a Green Analytical Method of RP-HPLC for Quantification of Cefepime Hydrochloride in Pharmaceutical Dosage Form: Simple, Sensitive and Economic
- Development and Validation of a New Method to Quantify Pilocarpine in Tablets by HPLC-DAD
- Determination of Caffeine and its Metabolites in Saliva and Urine as a Measure of CYP1A2 Metabolic Activity
- Step by Step Method Development and Analytical Validation of L929 Bioassay for rTNF-α Potency Evaluation in Manufacturing
- Estimation of Crotepoxide in the Fruits of Piper attenuatum Buch.-Ham. Using High-Performance Thin Layer Chromatography and High-Performance Liquid Chromatography
- Direct UHPLC-DAD Method to Determine Asenapine, Paroxetine and Fluvoxamine in Human Blood Serum, Urine and Cerebrospinal Fluid
- A Validated Chiral Liquid Chromatographic Method for the Enantiomeric Separation of Orphenadrine Citrate in Pharmaceutical Dosage Form
- A Novel Quantitative Spectrophotometric Method for the Analysis of Vigabatrin in Pure Form and in Pharmaceutical Formulation
- LC-MS for Determination of Three Methoxyflavones from Kaempferia parviflora in rat Plasma and Application to Pharmacokinetic Study
- Pharmacokinetics and Tissue Distribution of Fargesin After Oral Administration in Rats by High Performance Liquid Chromatography
- Quality Control Optimization Solutions for Determination of Rutin in Supplements Containing Ginkgo Biloba Extract
- Determination of Aliskiren Hemifumarate and Amlodipine Besylate in their combined Dosage form by Different Spectrophotometric Methods
For details on the articles, please visit this link :: http://bit.ly/2cWZ6lG
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Wednesday 5 October 2016
Current Pharmaceutical Analysis 12, Issue 3
Current Pharmaceutical Analysis publishes expert reviews and original research articles on all the most recent advances in pharmaceutical and biomedical analysis. All aspects of the field are represented including drug analysis, analytical methodology and instrumentation. The journal is essential to all involved in pharmaceutical, biochemical and clinical analysis.
Articles from the journal Current Pharmaceutical Analysis, Volume 12, Issue 3:
- Advances in Analyses of Profens in Biological and Environmental Samples by Liquid Chromatography
- Ion Selective Electrodes for Potentiometric Determination of Tizanidine in Its Pharmaceutical Dosage Form
- Analysis of Ursodeoxycholic Acid Using Ultra-performance Liquid Chromatography with Tandem Mass Spectrometry
- Enhancement of Dissolution Rate of Furosemide Using a Solid Dispersion with D-Glucosamine HCl
- Development and Validation of an HPLC Method for Quantitative Determination of Seven Impurities in Orlistat Capsules and Characterization of Two Novel Impurities
- Validation of a Rapid and Sensitive HPLC-UV Method for the Quantification of Eprosartan Mesylate in Bulk Drug, TeventenTM and Ultradeformable Lipid Based Vesicular System
- Quantitative Estimation of Lead (Pb) and Cadmium (Cd) Content in Commonly Used Cosmeceuticals Using Atomic Absorption Spectroscopy
- Acute Toxicity of Antibiotics in Surface Waters by Bioluminescence Test
- A Novel Monocyte-based Pyrogen Test Based on the Mechanism of Human Fever Reaction
- A Novel Monocyte-based Pyrogen Test Based on the Mechanism of Human Fever Reaction
- Stability Indicating Spectrofluorimetric Analysis of Metopimazine by Signal Enhanced – Partial Least Squares Chemometric Models: A Comparative Study
- Development of a Simple and Accurate RP-HPLC-UV for Determination of Choleretic Drug Alibendol in Human Plasma and Its Application for a Pharmacokinetic Study
- Fragmentation Study of Daphniphyllum Alkaloids by Electrospray Ionization Quadrupole Time-of-flight Mass Spectrometry
- A Novel Application of Three Phase Hollow Fiber Based Liquid Phase Microextraction (HF-LPME) for the HPLC Determination of Tamsulosin from Biological Fluids
- Stability-indicating TLC /Densitometric Method for Simultaneous Analysis of Febuxostat and Diclofenac Potassium in Bulk and Tablets
For details on the articles, please visit this link :: http://bit.ly/2aaKBfD
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Current Pharmaceutical Analysis Vol 12, Issue 1
Current Pharmaceutical Analysis publishes expert reviews and original research articles on all the most recent advances in pharmaceutical and biomedical analysis. All aspects of the field are represented including drug analysis, analytical methodology and instrumentation. The journal is essential to all involved in pharmaceutical, biochemical and clinical analysis.
Articles from the journal in Current Pharmaceutical Analysis, 12 issue 1:
- Critical Review of Malondialdehyde Analysis in Biological Samples
- Impurities and Forced Degradation Studies: A Review
- Mechanism of Metachromasy Induced by the Binding of Dissociated and Undissociated Bromocresol Purple to Separate Sites on Human Serum Albumin
- A Lack of Association Between Blood Glutamate and Anxiety Levels in Pre- delivery Pregnant Women
- Voltammetric Sensing of Uremic Toxin Indoxyl Sulfate Using High Performance Disposable Screen-Printed Graphene Electrode
- Failure Mode and Effects Analysis to Reduce Risks of Errors in the Good Manufacturing Practice Production of Engineered Cartilage for Autologous Chondrocyte Implantation
- Simultaneous Separation, Quantitation, and Determination of the Dissociation Constant of Five Components of Ixeris sonchifolia by Microemulsion Electrokinetic Chromatography
- Fast Determination of β-estradiol by Chromatographic Method and its Application to Clinical Pharmacokinetics Studies
- Effectiveness and Safety of Digoxin on Chronic Heart Failure
Download the issue from our website http://bit.ly/1iT6zlh
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BSP Journals Impacting Science: ‘Current Pharmaceutical Analysis’ and ‘Current Proteomics’
Current Pharmaceutical Analysis
Editor-in-Chief:
Atta-ur-Rahman, FRS
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK
Kings College
University of Cambridge
Cambridge
UK
Aims & Scope
Current Pharmaceutical Analysis publishes expert reviews and original research articles on all the most recent advances in pharmaceutical and biomedical analysis. All aspects of the field are represented including drug analysis, analytical methodology and instrumentation. The journal is essential to all involved in pharmaceutical, biochemical and clinical analysis.
Current Proteomics
Editor-in-Chief:
Bernd Rehm
Institute of Molecular BioSciences Massey University
Private Bag 11222
Palmerston North
New Zealand
Private Bag 11222
Palmerston North
New Zealand
Aims & Scope
Research in the emerging field of proteomics is growing at an extremely rapid rate. The principal aim of Current Proteomics is to publish well-timed review articles in this fast-expanding area on topics relevant and significant to the development of proteomics. Current Proteomics is an essential journal for everyone involved in proteomics and related fields in both academia and industry.
Current Proteomics publishes review articles in all aspects of the fast-expanding field of proteomics. All areas of proteomics are covered together with the methodology, softwares, databases, technological advances and applications of proteomics, including functional proteomics. Diverse technologies covered include but are not limited to:
|
|
In addition to in-depth reviews, articles highlighting recent proteomics papers of special interest as well as book reviews are published. Mini-reviews and perspective articles are also published. In view of the importance of specific technology and software developed for advancement of proteomics research, a separate section is devoted to product and technology reports. Proceedings of proteomics meetings with selected review articles on topics presented are also published.
courtesy by https://benthamsciencepublishers.wordpress.com/2014/06/26/bsp-journals-impacting-science-current-pharmaceutical-analysis-and-current-proteomics/
Recently Published Issue of The Journal: Current Pharmaceutical Analysis
Current Pharmaceutical Analysis publishes expert reviews and original research articles on all the most recent advances in pharmaceutical and biomedical analysis. All aspects of the field are represented including drug analysis, analytical methodology and instrumentation. The journal is essential to all involved in pharmaceutical, biochemical and clinical analysis.
Following are the articles recently published in the journalCurrent Pharmaceutical Analysis, 11 Issue 01:
Article: The Site-specific Protonation Constants of Spectinomycin, Characterized by 1H and 15N NMR Methods
Author(s): Mate Somlyay, Gabor Orgovan and Bela Noszal
Article: Application of Droplet Size Analysis for the Determination of the Required HLB of Lemon Oil in O/W Emulsion
Author(s): N.A. Niczinger, N. Kallai-Szabo, J. Dredan, L. Budai, M. Hajdu and I. Antal
Article: Electrochemical Analysis of Cyanuric Acid Using Polyaniline/CuGeO3 Nanowires as Electrode Modified Materials
Author(s): L.Z. Pei, H.D. Liu, N. Lin, Y.K. Xie and Z.Y. Cai
Article: Simultaneous Analysis of Losartan Potassium and its Related Impurities and Degradation Products in Tablets Using HPLC
Author(s): Shuhong Qiu, Kai Liu, Panqin Ma, Menglin Wang, Hongming Chen, Xiaochao Xu, Xiaoli Hao and Yongjun Wang
Article: LC-MS/MS Assay for Quantification of a Novel Antitubercular Molecule S006-830: Pharmacokinetic and Plasma Protein Binding Studies in Rats
Author(s): Mahendra Kumar Hidau, Yeshwant Singh, Sudhir Shahi, Poojari Mounika and Shio Kumar Singh
Article: Method Development & Validation of LCMS/MS for Atorvastatin and Olmesartan in Human Plasma to Trace Drug Interaction of Formulation
Author(s): Rakesh Das and T.K. Pal
Article: The Effect of Albumin-genotype on Ibuprofen Displacement of Nifedipine from its Binding Sites.
Author(s): Eman Atef and Ahmed S. Mehanna
Article: High Sensitivity C-reactive Protein and Cardiovascular Risk Prediction
Author(s): Andreja Trpkovic, Julijana Stanimirovic, Ivana Resanovic, Petar Otasevic, Danimir Jevremovic, Radak Djordje and Esma R. Isenovic
Article: Analysis of Tocopherols and Tocotrienols in Pharmaceuticals and Foods: A Critical Review
Author(s): Dan Lu, Yi Yang, Yongxin Li and Chengjun Sun
For details, please visit: http://bit.ly/1BjtM3A
courtesy by : https://benthamsciencepublishers.wordpress.com/2014/12/29/recently-published-issue-of-the-journal-current-pharmaceutical-analysis/
BSP Journals Impacting Science: ‘Current Pharmaceutical Analysis’
Current Pharmaceutical Analysis
Editor-in-Chief:
Atta-ur-Rahman, FRS
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK
Kings College
University of Cambridge
Cambridge
UK
Aims & Scope
Current Pharmaceutical Analysis publishes expert reviews and original research articles on all the most recent advances in pharmaceutical and biomedical analysis. All aspects of the field are represented including drug analysis, analytical methodology and instrumentation. The journal is essential to all involved in pharmaceutical, biochemical and clinical analysis.
Current Proteomics
Editor-in-Chief:
Bernd Rehm
Institute of Molecular BioSciences Massey University
Private Bag 11222
Palmerston North
New Zealand
Private Bag 11222
Palmerston North
New Zealand
Aims & Scope
Research in the emerging field of proteomics is growing at an extremely rapid rate. The principal aim of Current Proteomics is to publish well-timed review articles in this fast-expanding area on topics relevant and significant to the development of proteomics. Current Proteomics is an essential journal for everyone involved in proteomics and related fields in both academia and industry.
Current Proteomics publishes review articles in all aspects of the fast-expanding field of proteomics. All areas of proteomics are covered together with the methodology, softwares, databases, technological advances and applications of proteomics, including functional proteomics. Diverse technologies covered include but are not limited to:
|
|
In addition to in-depth reviews, articles highlighting recent proteomics papers of special interest as well as book reviews are published. Mini-reviews and perspective articles are also published. In view of the importance of specific technology and software developed for advancement of proteomics research, a separate section is devoted to product and technology reports. Proceedings of proteomics meetings with selected review articles on topics presented are also published.
courtesy by https://benthamsciencepublishers.wordpress.com/2014/06/26/bsp-journals-impacting-science-current-pharmaceutical-analysis-and-current-proteomics/